Clinical relevance of anti-PR3 capture ELISA in diagnosing Wegener's granulomatosis
نویسندگان
چکیده
منابع مشابه
Meningeal involvement in apparently ANCA-negative Wegener's granulomatosis: a role for PR3 capture-ELISA?
SIR, Central nervous system (CNS) involvement is rare in Wegener's granulomatosis (WG): the spectrum of CNS manifestations includes cerebrovascular events, seizures and cranial nerve abnormalities [1, 2]. Meningitis is exceedingly rare, and its diagnosis often challenging [1–3]. A 57-yr-old man was admitted to hospital because of untreatable headache, photophobia, neck stiffness and paranasal s...
متن کاملENT manifestations of Wegeners granulomatosis.
Wegeners granulomatosis is a necrotizing granulomatous vasculitis with multisystemic involvement. We present two cases of Wegener's presenting with otological manifestations as the first symptom. These symptoms are subtle and diagnosis may be easily overlooked. Hence a high index of suspicion is required. Early diagnosis and treatment goes a long way in improving the outcomes and in preventing ...
متن کاملThe Role of Anca and Anti-gbm Antibodies in Pulmonary- Renal Syndrom Due to Wegeners Granulomatosis
Pulmonary-renal syndrome (PRS) is defined as a diffuse alveolar hemorrhage and rapidly progressive glomerulonephritis. We present a retrospective study of 22 consecutive patients with Wegeners granulomatosis (WG). Logistic regression analysis and a Wilcoxon test were included in the statistics. Survival time death risk were assessed using the Kaplan-Meier estimator and the Cox proportional haz...
متن کاملNeutrophil chemotaxis in Wegeners granulomatosis and idiopathic pulmonary fibrosis
Background: The presence of anti-neutrophil cytoplasmic antibodies (ANCA) in Wegeners granulomatosis (WG), implicate the neutrophil as a key effector cell. Previous studies have reported elevated neutrophil counts in the lung although the determinants of neutrophil chemotaxis in the WG lung are unknown. Methods: BALF cell counts, myeloperoxidase (MPO) and chemokines were measured in 27 patient...
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Recently it has been reported, that immunoglobulin Y (IgY) can be used instead of polyclonal antibodies extracted from mammals (IgG) for the purpose of diagnosis and therapy. These antibodies are found to have better properties in terms of specificity and ease of large-scale production. In addition, IgY binds neither to mammalian complement or Fc-receptors nor does it interfere with rheumatoid ...
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ژورنال
عنوان ژورنال: Journal of Clinical Laboratory Analysis
سال: 2008
ISSN: 0887-8013,1098-2825
DOI: 10.1002/jcla.20204